Hankins put up a career-high 26 points on 7-of-8 shooting and a 6-of-6 mark from beyond the arc. His perfect percentage from range ties him for the school single game record.
Meanwhile, VandeMerkt tallied 20 points and five boards after going 8-of-11 from the floor.
VandeMerkt was also 4-of-5 from the foul line. His lone miss broke a personal streak of 23 consecutive free throws made.
DePauw also had plenty of other contributions. David Vogel scored 16 and dished out a career-high seven assists.
Nolan Ginther scored a career-high 14 in his first start. Nicke Felke added 10 points and five assists.
DePauw, who shot 65 percent in their 83-70 win at Granville on Jan. 10, shot even better Wednesday at 67 percent (32-of-48). They shot a remarkable 71 percent (10-of-14) from 3-point range and 75 percent (21-of-28) from the foul line.
Their counterparts shot 54 percent from the floor (30-of-56), 45 percent from 3-point range (13-of-29) and 88 percent (14-of-16) from the line. Matt Doyle scored 15 to lead the Big Red.
DePauw outscored Denison's bench 49-7. They also held the advantage in the paint 38-34 and outrebounded the Big Red 25-20.
After DePauw scored the game's first three points, Denison scored the next nine. However, with 8:40 left in the half DePauw got the game back to even at 21-21 and later went up at halftime 42-37.
The Tigers distanced themselves and led by as many as 15 at 62-47 with 11:42 remaining. The closest Denison got to taking the lead back was at 77-75 with just under four minutes remaining. However, that sparked an 8-0 run from DePauw that eventually sealed the game.
DePauw's third straight win brings them to 10-12 overall and 6-9 in the NCAC. Denison drops to 11-11 and 7-8 in conference play.
DePauw heads to Kenyon for a 3 p.m. game on Saturday.